IMPAIRING BETA-OXIDATION CONTRIBUTES TO LIPOTOXICITY IN DIABETIC CARDIOMYOPATHY
نویسندگان
چکیده
منابع مشابه
Lipotoxicity in type 2 diabetic cardiomyopathy.
As obesity and type 2 diabetes are becoming an epidemic in westernized countries, the incidence and prevalence of obesity- and diabetes-related co-morbidities are increasing. In type 2 diabetes ectopic lipid accumulation in the heart has been associated with cardiac dysfunction and apoptosis, a process termed lipotoxicity. Since cardiovascular diseases are the main cause of death in diabetic pa...
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BACKGROUND/AIMS Experimental and clinical studies have shown the direct toxic effects of cigarette smoke (CS) on the myocardium, independent of vascular effects. However, the underlying mechanisms are not well known. METHODS Wistar rats were allocated to control (C) and cigarette smoke (CS) groups. CS rats were exposed to cigarette smoke for 2 months. RESULTS After that morphometric, functi...
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R failure is a common and serious complication of longstanding diabetes mellitus. Diabetes is now the most common cause of end-stage renal failure requiring dialysis in the United States, accounting for almost 40% of all new dialysis patients (1). Moreover, the incidence of renal failure caused by diabetes, particularly type II diabetes, is rising dramatically worldwide (2). Compounding the tra...
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BACKGROUND Obesity-related diabetes mellitus leads to increased myocardial uptake and oxidation of fatty acids, resulting in a form of cardiac dysfunction referred to as lipotoxic cardiomyopathy. We have shown previously that Astragalus polysaccharides (APS) administration was sufficient to improve the systemic metabolic disorder and cardiac dysfunction in diabetic models. METHODOLOGY/PRINCIP...
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Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in susceptibility to type 2 diabetes mellitus-associated nephropathy (T2DN), a pathway that had previously been unexplored. A genome-wide association study in Japanese patients identified a single nucleotide polym...
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ژورنال
عنوان ژورنال: Canadian Journal of Cardiology
سال: 2015
ISSN: 0828-282X
DOI: 10.1016/j.cjca.2015.07.312